The study found that brain metastases in melanoma had a weaker immune response compared to primary skin, lymph node, and other metastatic sites, suggesting reduced immune cell infiltration and expression of immune checkpoint inhibitor targets.
Metastatic triple-negative breast cancer (TNBC) exhibits increased inflammation and higher expression of checkpoint targets compared to non-TNBC cases, with a paradoxical finding that lower PD-L1 expression is associated with better overall survival.
