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Molecular Tumor Board: 71-year-old male with gastrointestinal stromal tumor and KIT A502_Y503dup

In this recent Molecular Tumor Board, our Medical Affairs team reviewed a case of gastrointestinal stromal tumor (GIST) with a confirmed KIT mutation, highlighting how NGS-based Comprehensive Genomic Profiling (CGP) informs treatment. The discussion explored the biology of the kinase family and how molecular testing can differentiate alterations that may be sensitive or resistant to specific kinase inhibitors. This case underscores the power of precision medicine in guiding targeted therapy and improving outcomes in GIST.

Puerto Rico

Puerto Rico
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September 25, 2025

The PROstate Cancer Registry in Large Patient Population AIMed to Assess Efficacy in Germline Testing (PROCLAIM) Study

The PROCLAIM study determined the prevalence of pathogenic germline variants (PGVs) and their impact on treatment and management in a diverse cohort of patients with prostate cancer. The findings suggest that testing guidelines for hereditary cancer genetic testing in patients with prostate cancer are restrictive and may miss patients with pathogenic germline variants whose treatment and follow-up care recommendations may be changed based on their genetic test result.