This study reports a prespecified exploratory biomarker analysis of the Phase III PARAGIGM trial, which demonstrated increased overall survival with first-line anti-EGFR (panitumumab) therapy as compared with anti-vascular endothelial growth factor (bevacizumab) therapy in combination with modified FOLFOX6 in RAS wild-type metastatic colorectal ca
This molecular tumor board reviews tumor-agnostic biomarker testing and targeted therapy selection for RET alterations in a patient with advanced pancreatic ductal adenocarcinoma. We also provide an overview of risk factors, prognosis and biomarker-driven therapy selection underscoring the importance of comprehensive genomic profiling in patients with advanced pancreatic cancer.
Cancer-testis antigens (CTAs) are tumor antigens normally expressed in the testes but are aberrantly expressed in several cancers. Overexpression of CTAs has been shown to drive cancer metastasis. R.J.
This latest molecular tumor board reviews a case of a 68 year-old female with metastatic lung adenocarcinoma with an EGFR L848R mutation. Frontline biomarker testing provided initial options for therapy, but at progression liquid biopsy testing was confounded by clonal hematopoiesis.
Recognizing and mitigating cancer treatment toxicities is an essential piece of a survivorship plan after curaing cancer. Our latest molecular tumor board discusses an important intersection of cardiology and oncology in breast cancer through a case of a 33-year-old female with locally advanced ER/PR-negative, HER2-positive breast cancer.