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Lung Cancer 

Labcorp Oncology offers a comprehensive test menu to assist in the diagnosis and management of patients with lung cancer throughout their continuum of care.

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  Diagnostic  |  Prognostic  |  Predictive 

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Diagnostic

Diagnostic

Complex Tumor Analysis by IHC

Our extensive antibody library and team of pathologists can provide a differential diagnostic analysis in even the most difficult cases.

  • Squamous cell vs. adenocarcinoma
  • Adenocarcinoma vs. Mesothelioma
  • Lung vs. Breast
  • Small cell vs. non-small cell carcinoma

Learn more about Complex Tumor Analysis by IHC

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Prognostic

Prognostic

KRAS Gene Mutation
Analysis, IVD

 The presence of a KRAS mutation is prognostic for poor survival.1

Learn more about KRAS Gene Mutation
Analysis, IVD

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Predictive

Predictive biomarkers for therapeutic selection

TestDetectsTherapy
ALK (D5F3) by IHCALK protein expressionalectinib2, brigatinib3, lorlatinib4, ceritinib5, crizotinib6
ALK by FISHALK rearrangements (translocations)alectinib2, brigatinib3, lorlatinib4, ceritinib5, crizotinib6
BRAF Gene Mutation AnalysisMutations in the BRAF gene (V600E)dabrafenib7 +/ trametinib8, vemurafenib9
EGFR Mutation Analysis Cobas V2 Assay (Plasma)Mutations in the EGFR geneosimertinib10, gefitinib11, erlotinib12, afatinib13,dacomitinib14
EGFR Mutation AnalysisMutations in the EGFR geneosimertinib10, gefitinib11, erlotinib12, afatinib13,dacomitinib14
EGFR by FISHEGFR amplificationosimertinib10, gefitinib11, erlotinib12, afatinib13,dacomitinib14
KRAS Mutation Analysis, IVDMutations in the KRAS gene (G12C)sotorasib15
MET by FISHMET amplificationcrizotinib6
OmniSeq INSIGHT, Solid Tumor NGS Panel (DNA and RNA)Next-generation sequencing panel of DNA and RNA (523 genes) and relevant immune biomarkers including  PD-L1 IHC, MSI, TMBTargeted therapies and immunotherapies
PD-L1 by IHC (SP263, SP142, 28-8 clones)PD-L1 protein expressionpembrolizumab16, nivolumab17, atezolizumab18
Resolution ctDx Lung Assay (Liquid Biopsy)23 actionable genes associated with biomarker directed therapy in NSCLCTargeted therapies
RET by FISHRET rearrangements (translocations)selpercatinib19, pralsetinib20, cabozantinib21
ROS1 by FISHROS1 rearrangements (translocations)crizotinib6, ceritinib5, entrectinib22

References

  1. Slebos, R.J., et al., K-ras oncogene activation as a prognostic marker in adenocarcinoma of the lung. N Engl J Med 1990 Aug 30;323(9):561-5. 
  2. ALECENSA® (alectinib) [package insert]. South San Francisco, CA: Genentech, Inc.; 2021.
  3. ALUNBRIGTM (brigatinib) [package insert]. Cambridge, MA: ARIAD Pharmaceuticals, Inc.; 2017.
  4. LORBRENA® (lorlatinib) [package insert]. New York, NY: Pfizer, Inc.; 2021.
  5. ZYKADIA® (ceritinib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2019.
  6. XALKORI® (crizotinib) [package insert]. New York, NY: Pfizer, Inc.; 2022.
  7. TAFINLAR® (dabrafenib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2018.
  8. MEKINIST® (trametinib) [package insert]. East Hanover, NJ: Novartis Pharmaceuticals Corporation; 2022.
  9. ZELBORAF® (vemurafenib) [package insert]. South San Francisco, CA: Genentech, Inc.; 2021.
  10. TAGRISSO® (osimertinib) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2020.
  11. IRESSA® (gefitinib) [package insert]. Wilmington, DE: AstraZeneca Pharmaceuticals LP; 2021.
  12. TARCEVA® (erlotinib) [package insert]. South San Francisco, CA: Genentech, Inc.; 2010.
  13. GILOTRIF® (afatinib) [package insert]. Ridgefield, CT: Boehringer Ingelheim Pharmaceuticals, Inc.; 2018.
  14. VIZIMPRO® (dacomitinib) [package insert]. New York, NY: Pfizer, Inc.; 2018.
  15.  LUMAKRAS™ (sotorasib) [package insert]. Thousand Oaks, CA: Amgen Inc.; 2021.
  16. KEYTRUDA® (pembrolizumab) [package insert]. Whitehouse Station, NJ: Merck &Co., Inc.; 2021.
  17. OPDIVO® (nivolumab) [package insert]. Princeton, NJ: : Bristol-Myers Squibb Company; 2018.
  18. TECENTRIQ® (atezolizumab) [package insert]. South San Francisco, CA: Genentech, Inc.; 2018.
  19. RETEVMO™ (selpercatinib) [package insert]. Indianapolis, IN: Lilly USA, LLC; 2021.
  20. GAVRETO™ (pralsetinib) [package insert]. Cambridge, MA: : Blueprint Medicines Corporation; 2020.
  21. CABOMETYX® (cabozantinib) [package insert]. Alameda, CA: Exelixis, Inc.; 2019.
  22. ROZLYTREK™ (entrectinib) [package insert]. South San Francisco, CA: Genentech, Inc.; 2019.