This review discusses the rationale behind molecular testing of patients with advanced NSCLC, highlights the benefits of comprehensive genomic profiling at diagnosis and presents four cases that demonstrate the need for tissue stewardship in the context of biomarker testing.
In this Molecular Tumor Board, we review a case of intrahepatic cholangiocarcinoma with an FGFR2 fusion. We provide an overview of the different subtypes, risk factors, and prognosis of cholangiocarcinoma. We’ll also discuss recent developments of targeted therapies including FGFR inhibitors that have improved the outlook for patients with this cancer.
Advances Labcorp strategy to launch and scale specialty testing in areas such as oncology and rare diseases Transaction requires court approval, with confirmation expected on May 6, 2024 BURLINGTON, N.C. , April 24, 2024 /PRNewswire/ -- Labcorp (NYSE: LH), a global leader of innovative and
In this real-world study of patients with advanced NSCLC treated with immune checkpoint inhibitors, integrated analysis of ctDNA and matched white blood cells measured molecular response through longitudinal liquid biopsy and more accurately predicted radiographic response and overall survival.
Contrived samples, prepared from cell line derived DNA and cell line derived DNA spiked into non-cancerous cfDNA plasma to mimic the features of cfDNA, facilitates robust testing of rare variants in clinical samples and further supports analytical validation studies.
PGDx elioTM plasma focus assesses cell-free DNA (cfDNA) to enable non-invasive genomic profiling with next-generation sequencing. This study characterized a range of pre-analytic factors including cfDNA fraction and yield across 293 clinical plasma samples.
In a discovery cohort of 24,186 solid tumors across 35 tumor histologies, comprehensive immune profiling assay using the OmniSeq® INSIGHT assay demonstrated significant co-expression of HIF-1α with downstream genes, especially those related to angiogenesis and novel gene signatures that characterize the hypoxic tumor microenvironment.