Using comprehensive genomic and immune profiling on discovery cohort of 24,186 solid tumors across 35 tumor types, this study confirmed that TIGIT expression is correlated with PD-L1 expression. Patients whose tumors express higher levels of TIGIT and PD-L1 via immunohistochemistry had improved overall survival. This study further highlights the potential use of immune profiling to develop new novel combination therapies and clinical trial design across solid tumors.