This latest molecular tumor board reviews a case of a 68 year-old female with metastatic lung adenocarcinoma with an EGFR L848R mutation. Frontline biomarker testing provided initial options for therapy, but at progression liquid biopsy testing was confounded by clonal hematopoiesis.
Circulating tumor DNA (ctDNA) can detect primary resistance to immunotherapy in patients with lung cancer. In the first stage of this phase 2 trial, we evaluated 50 patients with advanced non-small cell lung cancer who received standard of care pembrolizumab to determine ctDNA response and its concordance with imaging.