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Cancer Type
Breast, Gastroesophageal
Technology Used
IHC
Turnaround Time
2-4 days
Use
HER2 protein overexpression; FDA-approved test for detection of HER2/neu; prognostic and predictive indicator in breast carcinoma
Special Instructions
Clearly indicate clinical reason for testing provide the following information: differential diagnosis, site of specimen, and clinical information.
Test Includes
Option I: Slides and controls are returned for client interpretation
Option II: Slides and controls are returned with an immunostain interpretation
Option III: Full surgical pathology consultation (can be ordered with option II.)
Limitations
Use of fixatives other than 10% formalin may not yield equivalent or satisfactory results.
Methodology
Immunohistochemistry (IHC)
Specimen Requirements
Information on collection, storage, and volume
Specimen
Formalin-fixed paraffin embedded (FFPE) tissue block with Corresponding H&E, and/or unstained slides sectioned from tissue block. Precut slides from paraffin blocks in 5 micron sections.
Volume
0.2 cm x 0.2 cm x 0.2 cm tissue. Minimum of 2 slides per antibod in 5 micron sections
Storage Instructions
Store specimen at room temperature.
Collection
Tissue should be well-fixed in formalin. If alternative fixative is used, it should be noted on the requisition. Unstained Slides: Send all slides within 6 weeks of cutting.; Minimum of 2 slides per antibody. Mount on Poly-L-Lysine-coated or plus (+) slides. Air dry. Do not oven dry.
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