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FISH (Fluorescence in situ Hybridization ), Oncology

CPT Contact CPT coding department at 800-222-7566, ext 6-8400.

Test Details

Cancer Type

Hematologic malignancies, Leukemia, Lymphoma

Technology Used

FISH

Turnaround Time

3 - 5 days

View Requisition Forms

Use

This test is used for confirmation/identification of leukemia/lymphoma-related alterations and leukemia/lymphoma monitoring of residual disease, transplants and indolent clones (see list or call lab for probe availability).

Special Instructions

Call for additional probes not listed above. Pertinent clinical diagnosis, previous cytogenetic studies, and probe of interest should be included with the specimen (Call for a list of available probes or see online list.).

This test number is used for tracking oncology FISH specimens to the laboratory. Bill codes will be added when testing is complete, based on the processes performed in the laboratory.

Please provide targeted FISH probe and diagnosis. This test is essentially a tracking code, and the test will only be performed after the probes and diagnosis is provided. Absence of this information will delay turnaround time.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Information on collection, storage, and volume

Specimen

Whole blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slide with metaphase and/or interphase nuclei or bone marrow touch preparation slides are acceptable for testing.

Volume

Fixed-cell pellet, three slides, 10 mL blood (adult), 5 mL blood (pediatric), or 3 mL bone marrow

Minimum Volume

Fixed-cell pellet from a cytogenetic analysis, two slides, 5 mL blood (adult), 1 mL blood (pediatric), or 1 mL bone marrow

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; frozen specimen

Collection

Utilize sterile technique and Labcorp transport kits when possible.

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