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DDIT3 (CHOP) by FISH

CPT Contact CPT coding department at 800-222-7566, ext. 6-8400.
Synonyms
  • Leukemia FISH
  • Lymphoma FISH

Test Details

Technology Used

FISH

Turnaround Time

3 - 5 days

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Use

This test is used for confirmation/identification of cancer-related alterations (associated with myxoid liposarcomas/round liposarcomas).

Special Instructions

There will be an additional charge for processing paraffin block samples or for samples that require culture.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Information on collection, storage, and volume

Specimen

Fixed-cell pellet from a cytogenetic analysis, slides with metaphases and/or interphase nuclei or bone marrow touch prep slides; whole blood, bone marrow, cerebrospinal fluid (CSF), FNA, paraffin block are also acceptable with additional charge

Volume

5 mL whole blood (pediatric), 3 mL bone marrow, fixed-cell pellet from a cytogenetic analysis, 2 slides with metaphase and/or interphase nuclei, 2 touch preparation slides or 3 slides from paraffin block

Minimum Volume

1 mL whole blood (pediatric), 1 mL bone marrow, fixed-cell pellet  from cytogenetic analysis, 1 slide with metaphase and/or interphase nuclei, 1 touch preparation slide or 2 paraffin slides (Note: Minimum volumes may not allow for repeat testing.)

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Broken or dirty slides; excessive cellular debris or stained slides; decalcified bone cores; frozen specimen

Collection

Utilize sterile technique and Labcorp transport kits when possible.

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