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Reveal SNP Microarray - Oncology

CPT 81277
Synonyms
  • Reveal® Microarray

Test Details

Cancer Type

Acute lymphocytic leukemia (ALL), Acute myelocytic leukemia (AML), Chronic lymphocytic leukemia (CLL), Hematologic malignancies, Leukemia, Myeloma, Myelodysplastic syndrome (MDS)

Technology Used

Molecular

Turnaround Time

10 - 14 days

Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Special Instructions

Pertinent medical findings should accompany the test request form.

Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses more than 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

Specimen Requirements

Information on collection, storage, and volume

Specimen

Whole blood, bone marrow, or nonfixed tumor tissue

Volume

4 mL whole blood, 2 mL bone marrow, or >2 to 4 mm3 tissue

Minimum Volume

2 mL whole blood or 1 mL bone marrow for array only (Note: This volume does not allow for repeat testing.)

Container

Green-top (heparin) tube (preferred), yellow-top (ACD) tube, or lavender-top (EDTA) tube; sterile container containing sterile saline, Ringer's lactate, or Hanks' balanced salt solution or transport medium provided by the cytogenetic laboratory

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Quantity not sufficient for analysis; gel-separator tubes; microtainer tubes; fixed cell pellets