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Reveal SNP Microarray - Oncology

CPT 81277
Synonyms
  • Reveal® Microarray

Test Details

Cancer Type

Acute lymphocytic leukemia (ALL), Acute myelocytic leukemia (AML), Chronic lymphocytic leukemia (CLL), Hematologic malignancies, Leukemia, Myeloma, Myelodysplastic syndrome (MDS)

Technology Used

Molecular

Turnaround Time

10 - 14 days

View Requisition Forms

Use

This test will detect chromosomal imbalance that may be present in neoplastic disorders and clonal evolution. It provides detection of copy-neutral loss of heterozygosity of any chromosome, and the percent and location of homozygosity, that may be associated with cancer gene mutations.

Special Instructions

Pertinent medical findings should accompany the test request form.

Limitations

This SNP assay does not detect balanced rearrangements, low-level mosaicism (<10%), marker chromosomes that only that only contain heterochromatin or tetraploidy.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

SNP microarray analysis is performed using the Cytoscan® HD Accel platform, which uses more than 743,130 SNP probes and 2,029,441 NPCN probes with a median spacing of 0.818 kb.

Related Documents

For more information, please view the literature below.

 

    Specimen Requirements

    Information on collection, storage, and volume

    Specimen

    Whole blood, bone marrow or nonfixed tumor tissue

    Volume

    5 mL whole blood, 2 mL bone marrow or >2 to 4 mm3 tissue

    Minimum Volume

    2 mL whole blood or 1 mL bone marrow for array only (Note: This volume does not allow for repeat testing.)

    Container

    Whole blood or bone marrow: green-top (heparin) tube (preferred); or yellow-top (ACD) tube or lavender-top (EDTA) tube; nonfixed tumor tissue: sterile container containing sterile saline, Ringer's lactate or Hank's balanced salt solution or transport medium provided by the cytogenetic laboratory

    Storage Instructions

    Maintain specimen at room temperature.

    Causes for Rejection

    Upon receipt, suitability of specimen will be determined by the Cytogenetics laboratory.

    Collection

    Blood or bone marrow: using sterile technique, collect 5 mL of blood or 2 mL of bone marrow into a heparin, ACD or EDTA tube or syringe. Invert the tube several times to prevent coagulation. Specimens should be sent the same day as collected. 

    Nonfixed tumor tissue: Submit at room temperature using Lymph Node Transport Kit (supplied by Labcorp). Gel separator tubes, microtainer tubes and fixed cell pellets cannot be processed.

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