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The power of ctDNA testing in therapy selection and recurrence monitoring 

Liquid biopsy represents a transformation in the management of oncology patients given its potential to detect, characterize and monitor cancers earlier than can be achieved with conventional modalities. Due to its noninvasive nature, availability and accessibility, liquid biopsy offers an alternative sampling option when tissue is unavailable or insufficient.  

In this symposium, we demonstrate the following:

• The utility of an NGS-based ctDNA testing approach for therapy selection in advanced cancers   
• Tissue-agnostic treatment response monitoring in patients with metastatic colorectal cancer and its prognostic value in guiding treatment decisions
   

April 18, 2023
10:00 - 11:00 AM
Room: Exhibit Hall Theater C

Speakers

VIEW OUR POSTERS 
 

Session Category: Tumor Biology

#37   A novel technique to preclinically assess the ability of targeted therapies to inhibit both primary and metastatic non-small cell lung carcinoma 
Erin Trachet
Session Category: Tumor Biology 
Session Title: Novel Models of Human Cancer 
Location: Section 2 
Poster Board Number: 5 

#41   Subcutaneous growth and immune cell profiling of BT-474 human breast carcinoma in triple immunodeficient mice from multiple commercial vendors
Justin Snider 
Session Category: Tumor Biology 
Session Title: Novel Models of Human Cancer 
Location: Section 2 
Poster Board Number: 9 

#2402   Fractionated dosing: A more clinically relevant approach to radiotherapy in preclinical tumor models 
Kerry Ann Bright 
Session Category: Tumor Biology 
Session Title: Radiation Sciences 
Location: Section 3 
Poster Board Number: 2 

#4654   Differential immunomodulation following checkpoint blockade in the orthotopic ID8-luc ovarian model 
Sheri Barnes 
Session Category: Tumor Biology 
Session Title: Inflammation and Tumor Progression 
Location: Section 5 
Poster Board Number: 11 

#4561   3D Reconstructed Pancreas: A model capturing the unique tumor microenvironment and stromal architecture of pancreatic cancer 
Dr. Uihlein (Predictive Oncology) 
Session Category: Tumor Biology 
Session Title: 3D and Tissue Recombinant Models 
Location: Section 2 
Poster Board Number: 12 

#5945   Transcriptional analysis of TME in MC38 colon carcinoma model following checkpoint inhibition 
Priyanka Singh 
Session Category: Tumor Biology 
Session Title: Tumor-Stromal Cell (Including Immune Cell) Interactions and Therapy Responses 
Location: Section 7 
Poster Board Number: 6 

Session Category: Experimental and Molecular Therapeutics 

#589   Long-term acclimation of target cell lines to tumor microenvironment culture condition provides mechanistic insights into cell therapy effectiveness 
James Lim (Xcell Bio)
Session Category: Experimental and Molecular Therapeutics 
Session Title: Targeting the Tumor Microenvironment 
Location: Section 20 
Poster Board Number: 23 

#2749   Preclinical assessment of chimeric antigen receptor (CAR) T persistence and functionality in the disseminated NALM6-Luc human B cell acute lymphoblastic leukemia (ALL) model 
Dave Draper 
Session Category: Experimental and Molecular Therapeutics 
Session Title: Innovative Assay Technologies 
Location: Section 17 
Poster Board Number: 3 

#2762    Inhibition of Murine Myeloid Suppressor Cells Increases CD8+ T cell Activation in Vitro 
Anita Zaitouna 
Session Category: Experimental and Molecular Therapeutics 
Session Title: Innovative Assay Technologies 
Location: Section 17 
Poster Board Number: 16 

Session Category: Immunology

#1782   Functional potency assay predicts CAR-T effectiveness in tumor microenvironment 
Yelena Bronevetsky (Xcell Bio) 
Session Category: Immunology 
Session Title: CAR T-cell Therapy 
Location: Section 22 
Poster Board Number: 16 

Session Category: Clinical Research Excluding Trials

#3358   PLCRC-PROVENC3: Assessing the prognostic value of post-surgery liquid biopsy cell-free circulating tumor DNA in stage III colon cancer patients.
Carmen Rubio Alarcón
Session Category: Clinical Research Excluding Trials
Session Title: PO.CL01.16 - Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 3
Location: Section 43
Poster Board Number: 1
 
#5452   Complimentary use of DNA- and RNA-based NGS assays optimizes detection of clinically relevant translocations for comprehensive genomic profiling
Rongqin Ren
Session Category: Clinical Research Excluding Trials
Session Title: Biomarkers of Therapeutic Benefit 5
Location: Section 37
Poster Board Number: 2

#5587   Ultra-deep targeted sequencing of cell-free DNA and patient-matched white blood cells for treatment response evaluation in patients with metastatic colorectal cancer.
Iris van ‘t Erve
Session Category: Clinical Research Excluding Trials
Session Title: PO.CL01.17 - Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 4
Location: Section 41
Poster Board Number: 11

#5597   Enhanced detection and classification of cell-free DNA alterations through matched normal analyses with PGDx elio plasma complete
Tonya N. Watkins
Session Category: Clinical Research Excluding Trials
Session Title: PO.CL01.17 - Liquid Biopsies: Circulating Nucleic Acids and Circulating Tumor Cells 4
Location:  Section 41
Poster Board Number: 21

#923   Genomic landscape of patients with non-small cell lung cancer.
Neeraj Kumar Singh
Session Category: Clinical Research Excluding Trials    
Session Title: PO.CL11.01 - Analyses Using Clinical and Genomic Databases
Location: Section 38
Poster Board Number: 6

Session Category: Experimental and Molecular Therapeutics  

#6220   Development of a mutation profiling NGS assay to facilitate clinical decisions in hematologic malignancies.
Grant Hogg
Session Category: Experimental and Molecular Therapeutics        
Session Title: DNA Repair / Molecular Classification of Tumors for Diagnostics, Prognostics, and Therapeutic Outcomes / Others
Location: Section 18
Poster Board Number: 22

Session Category: Clinical Trials  

#CT212   A ctDNA-directed, multi-center phase II study of molecular response adaptive immuno-chemotherapy in patients with non-small cell lung cancer: Analysis of Stage 1 of CCTG BR.36
Valsamo Anagnostou
Session Category: Clinical Trials    
Session Title: PO.CT02.02 - Phase II Clinical Trials 2
Location: Section 47
Poster Board Number: 2