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Products and Services
Cancer Type
Supplies & Tools
Scientific Focus
1-3 days
CLL-MRD testing utilizes a 12-antibody flow cytometry panel in concert with a sequential gating strategy to isolate pure CLL B-cells from normal B-cells and regenerating cells. This process allows for the differentiation of 1 CLL cell in 10,000 normal B-cells and provides a quantitative measurement of the MRD status of patients with CLL who are undergoing therapy. Patients who achieve CLL-MRD-negative status have improved overall and progression-free survival. This test is not suitable for making primary diagnosis or monitoring untreated CLL patients with a high tumor load.
There must be a minimum of 5 million cells in the specimen submitted to perform the test (10 million cells preferred).
Flow Cytometry
Information on collection, storage, and volume
Whole blood or bone marrow
10 mL whole blood; 2 mL bone marrow aspirate
Green-top (sodium heparin) tube (preferred) or lavender-top (EDTA)
Maintain specimen at room temperature.
Hemolysis; specimen clotted; specimen frozen; specimen in formalin or other fixative; blood more than 72 hours old; bone marrow aspirates more than five days old; bags or bottles of body fluid or bronchial washing; tissue in formalin or other fixative; contaminated transport medium
All specimens should be shipped to Labcorp Oncology on the day of excision. Delay in shipping may compromise cell viability and results.
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