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Cancer Type
Head and neck, Infectious diseases, Uterine
Technology Used
IHC, ISH
Turnaround Time
2-4 days
Use
Identifies particular infectious agents
Special Instructions
Send all slides within 6 weeks of cutting.
Test Includes
The following are performed by IHC: Adenovirus CMV EBV (LMPI) Heliocobacter pylori (H. pylori) Hepatitis B Surface Antigen (HBsAg) Hepatitis B Core Antigen Hepatitis C Antigen (HBcAg) Hepatitis C Antigen (HCAg) Herpes Simplex Virus (HSVI/HSVII) Parvovirus Pneumocystis carinii (P.Carinii) Toxoplasma (TOXO) Varicella Zoster Virus (VZV) The following are performed by ISH: Epstein Barr Virus (EBER), Progressive multifocal leukoencephalopathy virus (PML) Human Papilloma Virus (HPV) Subtypes (6/11, 16/18, 31/33) KAPPA LAMBDA
Limitations
Only formalin-fixed tissue will be accepted for ISH testing
Methodology
Immunohistochemistry (IHC) / In Situ Hybridization (ISH)
Specimen Requirements
Information on collection, storage, and volume
Specimen
Formalin-fixed paraffin embedded (FFPE) tissue block with Corresponding H&E
Volume
0.2 cm x 0.2 cm x 0.2 cm tissue; 10-12 slides should for HPV testing; 6-8 slides for JC and EBER Virus testing
Storage Instructions
Store specimens at room temperature (20-23.5°C). Use cold pack for transport. Be sure cold pack is not in direct contact with specimen during transport.
Collection
Tissue should be well-fixed in formalin. If alternative fixative is used it should be noted on the requisition.
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