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GIST (gastrointestinal stromal tumor) Comprehensive Diagnostic Evaluation

CPT Dependent on specific testing performed

Test Details

Cancer Type

Gastrointestinal stromal tumor (GIST)

Technology Used

IHC, Molecular

Turnaround Time

4-21 days
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Use

Full diagnostic workup for gastrointestinal stromal tumors (GIST) including IHC and molecular analysis.

Test Includes

IHC and molecular analysis directed by a pathologist; includes c-KIT (CD117), CD34, DOG1, desmin, SMA, S100 by IHC. If tumor is positive for c-KIT or DOG1 expression by IHC, c-KIT gene mutation analysis will be performed. If no mutation is detected in exons 9, 11, 13, and 17 of the c-KIT gene, PDGFRA gene mutation analysis and BRAF gene mutation analysis will be performed.

Methodology

IHC , PCR

Specimen Requirements

Information on collection, storage, and volume

Specimen

Formalin-fixed, paraffin-embedded (FFPE) tissue block with corresponding H&E

Volume

10-μM sections and a matching H&E reference slide; 0.2 cm x 0.2 cm x 0.2 cm tissue with >50% tumor

Container

Slides or blocks

Storage Instructions

Store specimen at room temperature (20-23.5° C). Use cold pack for transport. Be sure cold pack is not in direct contact with specimen during transport.

Causes for Rejection

Tumor block containing insufficient tumor tissue or tumor fixed in a heavy metal fixative; broken or stained slides

Collection

Please provide a copy of the pathology report. Tissue should be well-fixed in formalin. If alternative fixative is used, it should be noted on the requisition..
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