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B-ALL FISH Profile (Philadelphia-like)

CPT Contact CPT coding department at 800-222-7566, ext. 6-8400.

Test Details

Turnaround Time

5 days

View Requisition Forms

Use

This test is used for leukemia/lymphoma monitoring of residual disease, transplants and indolent clones.

Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetic studies on the test request form if available.

Test Includes

This test includes FISH probes, ABL1, ABL2, CFRL2, JAK2 and PDGFRB.

Limitations

Molecular mutations below the resolution of FISH will not be detected. This test will not detect regions not targeted by FISH probes in this panel.

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Fluorescence in situ hybridization (FISH)

Specimen Requirements

Information on collection, storage, and volume

Specimen

Blood, bone marrow, CSF, fixed-cell pellet from a cytogenetic analysis, slides with metaphase and/or interphase nuclei or bone marrow touch prep slides are acceptable for testing

Volume

10 mL blood (adult), 5 mL blood (pediatric), 3 mL bone marrow

Minimum Volume

5 mL blood (adult), 1 mL blood (pediatric), 1 mL bone marrow

Container

Green-top (sodium heparin) tube (pediatric Vacutainer is optimal, lavender-top (EDTA) tube is suboptimal); adjust tube size to sample volume to avoid heparin toxicity

Causes for Rejection

Broken Vacutainer; broken or stained slides; paraffin blocks; paraffin slides; decalcified bone cores; frozen specimen; quantity not sufficient for analysis

Collection

Transporting to the testing lab at room temperature is acceptable. Do not allow the sample to overheat or freeze. Use a cool pack or Labcorp transport kit if necessary. Specimens should optimally arrive in the laboratory within 48 hours of collection. Indicate date of collection on the test request form.

Request Supplies