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ALK Gene Rearrangements

CPT Call client services.
Synonyms
  • NSCLC ALK FISH
  • Oncology FISH

Test Details

Cancer Type

Hematologic malignancies, Lung, Non-small cell lung cancer

Technology Used

FISH

Turnaround Time

4 - 6 days

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Use

Confirmation/identification of non−small-cell lung cancer. This is an FDA-approved test for the identification of NSCLC patients who may be eligible for treatment.

Special Instructions

Pertinent clinical diagnosis, including the pathology report documenting pulmonary origin, should be included with the specimen. Additional charges will be applied for the embedding process if formalin-fixed tissue is submitted.

Methodology

Fluorescence in situ hybridization (FISH) from formalin-fixed paraffin-embedded (FFPE) tissue (4-micron to 5-micron sections); H&E for pathology review

Specimen Requirements

Information on collection, storage, and volume

Specimen

Formalin-fixed paraffin-embedded (FFPE) tissue

Volume

Five slides (4‐ to 5‐micron thick sections)

Minimum Volume

Two slides (4‐ to 5‐micron thick sections)

Container

Paraffin block

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Improper embedded prep; poor fixation <6 hours and >72 hours; decalcified bones or bone core; broken or dirty slides; absence of tumor or quantity not sufficient for analysis

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