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Multiple Myeloma (MM) FISH Profile

CPT Contact CPT coding department at 800-222-7566, ext 6-8400.
Synonyms
  • Monoclonal Gammopathy of Undetermined Significance (MGUS)
  • Plasma Cell Leukemia

Test Details

Cancer Type

Hematologic malignancies, Myeloma

Technology Used

FISH

Turnaround Time

5 - 7 days

View Requisition Forms

Use

This is a diagnostic test for multiple myeloma. Plasma cell enrichment diagnosis increased as much as 50% to 100%. The FISH results on the enriched assay should not be used as a quantitative assay, since the abnormal cells do not represent the percentage of abnormal cells in the aspirate.

Special Instructions

Indicate pertinent clinical diagnosis and previous cytogenetics studies on the test request form. If insufficient plasma cells are available, the following probe priority will be followed: Previous abnormality, p53, FGFR3/IGH, MAF/IGH, 1p/1q, 13q14, CCND1/IGH, 7/9/15 aneuploidy probes. If a chromosome study (510999) is ordered concurrently and sample is not sufficient for both tests, FISH will be prioritized.

Test Includes

Fluorescence in situ hybridization (FISH) for multiple myeloma (MM), targeting 13q14, IGH/CCND1, TP53, FGFR1/IGH, cMAF/IGH, amplification of 1p/1q, on plasma enriched cells.

Limitations

Molecular mutations or chromosomal alterations not targeted by the probe included in this profile will not be detected. 

This test was developed and its performance characteristics determined by Labcorp. It has not been cleared or approved by the Food and Drug Administration.

Methodology

Fluorescence in situ hybridization (FISH) and plasma cell enrichment

Specimen Requirements

Information on collection, storage, and volume

Specimen

Bone marrow

Volume

1 to 3 mL bone marrow

Minimum Volume

1 mL bone marrow

Container

Green-top (sodium heparin) tube; pediatric Vacutainer® is optimal or lavender-top (EDTA) tube (suboptimal). For samples with shared karyotype (510999) and any FISH study in the same tube, EDTA is not recommended due to the growth inhibition in cell culture. Adjust tube size to sample volume to avoid heparin toxicity.

Storage Instructions

Maintain specimen at room temperature.

Causes for Rejection

Whole blood; broken Vacutainer®; specimen received at testing facility 72 hours after collection

Collection

Utilize sterile technique and Labcorp transport kits when possible.

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